Endocrine Abstracts

Introduction: In 2014 the diabetes multidisciplinary team at Gloucestershire Royal Hospital Foundation Trust introduced dedicated annual review clinics for children with type I diabetes over the age of 8 years. Children receive their Consultant appointment, foot check, annual review bloods and structured education sessions in a single afternoon clinic visit. We present the results of two annual service evaluation projects, which have helped us improve the clinics and allowed u...

Introduction: Vitamin D deficiency is known to cause adverse outcomes in Pregnancy and has shown to have an association with Gestational Diabetes MellitusAim: To evaluate the relationship between GDM and Vitamin DMaterials and Methods: Retrospective study where we looked into the Vitamin D levels (deficient <25 nmol/l - G1, Insufficient 25-50 nmol/l - G2, Sufficient >50 nmo...

Background: Although small bowel (SB) neuroendocrine tumours (SBNETs) often present as indolent lesions, late diagnosis may result in poor outcomes. Successful management is therefore dependent on early identification. Double-balloon enteroscopy (DBE) enables direct SB mucosal visualisation, sampling and endotherapy. Our aim was to evaluate the role of DBE for early diagnosis and management of SBNETs.Methods: Retrospective review of all SBNETs diagnosed/...

Choroidal metastases were first reported by Perls in 1872. The choroid is the most common ocular site for metastatic disease due to the abundant blood supply. Bilateral lesions are commonly associated with breast carcinoma (40–47%) and unilateral with lung (21–29%). Treatment frequently depends on the patient status but includes observation, systemic chemotherapy, immunotherapy, hormone therapy, radiotherapy, plaque therapy, or photodynamic therapy. Neuroendocrine tu...

Introduction: Congenital lipoid adrenal hyperplasia (CLAH) is rare and caused by mutations in the steroidogenic acute regulatory (STAR) gene, which is involved in a key step in the synthesis of pregnenolone from cholesterol. Cases typically present in the first days of life with severe adrenal crisis, salt wasting and severely disrupted androgen secretion which may result in sex reversal in 46, XY individuals.Case report: We present a 21-month-o...

Background: Accurate evaluation of growth is a key assessment of child health, in the UK use of a paper growth chart is currently standard practice. Our trust had a drive to become paper light thus there needed to be a way to store growth data electronically. Growth data is often incompletely documented. A previous review of children’s outpatient attendances at our hospital found that across medical, surgical and tertiary specialties only 33% of children had growth data d...

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

Background: The importance of vitamin D supplementation in pregnancy is well known. Hypovitaminosis D is associated with adverse maternal and foetal outcomes such as pre-eclampsia, gestational diabetes mellitus, bacterial vaginosis, increased incidence of caesarean section delivery, intra-uterine growth restriction and reduced bone and muscle mass in childhood. The recommendations for vitamin D supplementation vary widely, with NICE guidelines suggesting a daily replacement do...

Vitamin D binding protein (VDBP) has a critical role in orchestrating optimal vitamin D homeostasis and bioavailability. VDBP has been implicated in modulating the gene expression of amino-transporters within the placenta and might thus control the transfer of amino acids to neonates during in utero development. We hypothesize that dyshomeostasis of VDBP could lead to adverse metabolic profiles and low birth weight in neonates. VDBP genetic polymorphisms steer the uni...

A major limitation of nutritional science is the objective assessment of dietary intake in free-living populations. Monitoring individuals’ response to policy recommendations is based on self-reported dietary assessment tools, which are known to have high misreporting rates estimated at 30–88%. We have developed a novel analytical pipeline capable to classify people into consumers of a healthy or unhealthy diet based on urinary metabolic patterns, without relying on ...